Synthesis of new cyclic and acyclic 5-halouridine derivatives as potential antiviral agents

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Autor/in:
Erscheinungsjahr:
2009
Medientyp:
Text
Schlagworte:
  • Reverse Transcriptase Inhibitors
  • HIV-1
  • Inhibitors NNRTIs
  • HIV
  • HIV Infections
  • Drugs
  • Antiviral agents
  • Bioorganic chemistry
  • Glycosylation
  • Nucleo-sides
  • Reverse Transcriptase Inhibitors
  • HIV-1
  • Inhibitors NNRTIs
  • HIV
  • HIV Infections
Beschreibung:
  • The synthesis of new cyclic and acyclic nucleoside analogues was achieved by alkylation of 5-halogenated 6-(2,4-dichlo-rophenoxymethyl)pyrimidine-2,4- dione following the Vorbrüggen coupling procedure. Nucleoside analogues of the 1-[(2-hydroxy-ethoxy)methyl]-6-(phenylthio)thymine (HEPT)-type were obtained as well as analogues of ganciclovir, acyclovir, and ribonucleosides. All compounds were tested against a variety of viruses. Three of the new compounds were potent and selective anti-HIV-1 inhibitors. © Georg Thieme Verlag Stuttgart.
Lizenz:
  • info:eu-repo/semantics/closedAccess
Quellsystem:
Forschungsinformationssystem der UHH
Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/ccba4c58-2622-48f9-a4c8-4111546c070a