Aircraft concepts and technologies can be assessed in various ways, targeting several key performance indicators. They can be assessed on mission level, fleet level or global air transport level. In this paper a fleet level direct operating cost (DOC) assessment of an advanced all new mid-range aircraft is performed. In a first step, range dependent DOC and seat mile cost (SMC) characteristics are provided for various aircraft. The new mid-range aircraft concept is then integrated into a fleet composition and compared to a baseline fleet scenario with the respective fleet level direct operating cost.