Media are central for communicating science and its achievements to the public, for the public’s discussion of science, and for transferring public opinions and perspectives back into science. In this chapter, we focus on the representations of systems biology in German and Austrian print media. The public perception is analyzed both quantitatively and qualitatively and focuses on the images of systems biology communicated to the public, including its application, research funding, and regulation. These images are derived from an analysis of metaphors that enables us to describe the underlying metaphorical frames and concepts. As we take into account the national differences and compare the public images of systems biology in Germany and Austria, we find some significant differences between both countries in the predominant metaphorical frames. The public image is well reflected in these metaphors, and we suggest that they have an important role in the public understanding of systems biology.