We herein report a robust and safe palladium catalyzed domino‐carbonylation/Suzuki–Miyaura cross‐coupling reaction of vinyltosylates with arylboronic acids using Mo(CO)6 as CO‐source. The derived γ‐keto ester were subsequently cyclized under acidic conditions to obtain γ‐hydroxybutenolides, an important structural motif, which occurs in biologically active natural products.