Conclusions: - Collaborative design approach for aircraft in pre-design: Enabling physics based analysis. Focus on flexibility effects. - Integration of distributed physics based modules: Analysis starting from an initial OAD synthesis model. Disciplinary modules for aero-structural design and new synthesis. Flexibility loop influence. - Design cases: Conventional aircraft behaves as expected. Care has to be considered with the unconventional aircraft case. - Outlook: Adopt the approach for design and optimization applications.