Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection.

Link:
Autor/in:
Erscheinungsjahr:
2011
Medientyp:
Text
Schlagworte:
  • Humans
  • Male
  • Female
  • Middle Aged
  • Treatment Outcome
  • Genotype
  • Viral Load
  • Drug Therapy, Combination
  • Hepatitis C, Chronic/*drug therapy/virology
  • Antiviral Agents/adverse effects/*therapeutic use
  • Hepacivirus/*drug effects/genetics
  • Oligopeptides/adverse effects/*therapeutic use
  • Protease Inhibitors/adverse effects/therapeutic use
  • RNA Replicase/*antagonists & inhibitors
  • RNA, Viral/analysis/blood/drug effects
  • Ribavirin/adverse effects/*therapeutic use
  • Thiazoles/adverse effects/*therapeutic use
  • Viral Nonstructural Proteins/antagonists & inhibitors
  • Humans
  • Male
  • Female
  • Middle Aged
  • Treatment Outcome
  • Genotype
  • Viral Load
  • Drug Therapy, Combination
  • Hepatitis C, Chronic/*drug therapy/virology
  • Antiviral Agents/adverse effects/*therapeutic use
  • Hepacivirus/*drug effects/genetics
  • Oligopeptides/adverse effects/*therapeutic use
  • Protease Inhibitors/adverse effects/therapeutic use
  • RNA Replicase/*antagonists & inhibitors
  • RNA, Viral/analysis/blood/drug effects
  • Ribavirin/adverse effects/*therapeutic use
  • Thiazoles/adverse effects/*therapeutic use
  • Viral Nonstructural Proteins/antagonists & inhibitors
Beschreibung:
  • Therapeutic regimens are being developed for patients with hepatitis C virus (HCV) infection that do not include the combination of peginterferon alfa and ribavirin. We investigated the antiviral effect and safety of BI 201335 (an inhibitor of the NS3/4A protease) and BI 207127 (an inhibitor of the NS5B non-nucleoside polymerase) with ribavirin.
  • Therapeutic regimens are being developed for patients with hepatitis C virus (HCV) infection that do not include the combination of peginterferon alfa and ribavirin. We investigated the antiviral effect and safety of BI 201335 (an inhibitor of the NS3/4A protease) and BI 207127 (an inhibitor of the NS5B non-nucleoside polymerase) with ribavirin.
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/20ea0ffd-49e6-4dee-b3f6-39cf41ffb567