Within the literature on warfare and drones two observations are currently made. The first is that war is becoming individualized and personalized; the second that warfare is more and more dehumanized. This juxtaposition of individualization and dehumanization within the literature is the departure point of this article. The article engages with the simultaneous individualization and dehumanization of warfare by assessing the relatively new practice of targeted killing via drones, focusing on the US drone programmes. Offering a short overview of current US drone strike practices and a reconstructive analysis of the discourse on targeted killing via drone strikes, the article identifies three themes within the discourse on targeted killing via drones: the language of the target, the language of the body, and the language of dehumanization. Taken together these themes are constitutive of the social construction of individual human beings as dehumanized targeted bodies. The article makes the argument that this social construction allows the conduct of dehumanized warfare against individual human beings. The article therefore provides a theoretical framework, which allows analysing and understanding the practice of the targeted killing via drones from a perspective of International Relations Theory