Following the discovery by AGILE (ATel #2855) and the confirmation by Fermi/LAT (ATel #2861) of enhanced gamma-ray emission from the Crab Nebula region in the time interval from Sept.18 to Sept.22, 2010, we have been granted a Hubble Space Telescope observation in the frame of the Director Discretionary time (program 12381). The observation, 2000 sec. long, centered on the Crab pulsar was performed by the ACS instrument (field of view 200 x 200 arcsec) equipped with filter F550M on Oct.2nd, 02:44 UT.