We have found a manifestation of spin-orbit Berry phase in the conductance of a mesoscopic loop with Rashba spin-orbit coupling placed in an external magnetic field perpendicular to the loop plane. In detail, the transmission probabilities for a straight quantum wire and for a quantum loop made of the same wire have been calculated and compared with each other. The difference between them has been investigated and identified with a manifestation of spin-orbit Berry phase. The non-adiabaticity effects at small radii of the loop have been found as well.