Total synthesis of (±)-paracaseolide A and initial attempts at a Lewis acid mediated dimerization of its putative biosynthetic precursor

Link:
Autor/in:
Erscheinungsjahr:
2013
Medientyp:
Text
Schlagworte:
  • Synthesis (chemical)
  • Alkenes
  • Reaction conditions
  • Synthesis (Chemical)
  • Rate Constants
  • Quinones
  • Synthesis (chemical)
  • Alkenes
  • Reaction conditions
  • Synthesis (Chemical)
  • Rate Constants
  • Quinones
Beschreibung:
  • A short (5 steps) and highly efficient (25\% overall yield) synthesis of paracaseolide A is described. Crucial steps are an alpha-iodination of a butenolide, a Suzuki coupling and a thermal Diels-Alder reaction. In attempts at Lewis acid catalyzed {[}4 + 2]-cycloadditions a set of novel dimerization products of the proposed biosynthetic paracaseolide A precursor were produced.
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem der UHH

Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/a448f262-c040-4ac3-9958-605237750283