PHARMACEUTICAL COMPOSITION COMPRISING MULTIPLE SUPPRESSOR TRANSFER RNAS

The invention relates, in one aspect, to pharmaceutical composition comprising at least five different suppressor transfer RNAs, wherein a) at least one of the suppressor transfer RNAs is able to base-pair to a UGA stop codon, at least one of the suppressor transfer RNAs is able to base-pair to a UAA stop codon, and at least one of the suppressor transfer RNAs is able to base-pair to a UAG stop codon; and b) the suppressor transfer RNAs are not all present in the composition in the same amount; and a pharmaceutically acceptable carrier.