Dimensioning function-critical components in automated manufacturing systems is critically and depends on the handled objects as well as the handling processes. The processes lead to mechanical forces and torques on the components. During engineering, these process-depending forces are mostly unknown and thus, are taken into consideration by using high safety factors. In order to reduce the resulting over-dimensioning a novel methodology, which facilitates all available information and new methods, is presented. By combining a Co-Simulation, consisting of FEM- and Multi-Physics-Simulations, with MBSE-approaches the digitized workflow iteratively converges the parameters of these critical components. A hardware-in-the-loop-approach assists gathering specific data and validating the final design-parameters.