A circular economy (CE), an alternative to the current take-make-waste economic model based on the gradual decoupling of economic activities from the consumption of finite virgin resources, cannot be implemented without the help of digital technologies, such as sensors, distributed ledgers, or analytics platforms, as key enablers. To mobilise the information systems (IS) field to help make the transition toward a CE, we outline several important areas of research that warrant our collective attention. Instead of presenting a list of research questions, we explore selected research challenges to stimulate both empirical research and novel solution-oriented theorising. We review hindrances that could undermine successful IS research on topics relevant to a CE and offer directions as pathways to building and evaluating the problem-solution pairing that could characterise a prolific CE–IS relationship.