Objectification is a recurrent criticism of psychiatry. But what is it more precisely? In the absence of a general theory, this chapter draws on various strands in the history of ideas, including Marxism and feminism, to distil key features. Central to objectification is the disregard for subjectivity and the reduction of persons to bodies. These elements also characterize biological psychiatry. Neurobiological explanations of disorders are to some degree inherently insensitive for the mental, as they presuppose the ‘real’ problem lies at the neurobiological level. Neurointerventions fall short of engaging with the subjectivity of recipients through a second-person stance. Accordingly, neurobiological explanations and interventions tend to objectify persons. This claim does not presuppose dubious mind–brain dualisms and might be sustained to some extent even if some form of neuroreductionism were true. However, the current emphasis on neurobiology and the supposed primacy of the brain in explaining and treating disorders is unfounded. No more than an indeed exciting research hypothesis, it should neither guide treatment decisions nor their ethical evaluation.