The long gamma-ray burst (GRB) 100621A, at the time the brightest X-ray transient ever detected by Swift-XRT in the $0.3\textrm{--}10$ keV range, has been observed with the H.E.S.S. imaging air Cherenkov telescope array, sensitive to gamma radiation in the very-high-energy (VHE, $>100$ GeV) regime. Due to its relatively small redshift of $z\sim0.5$, the favourable position in the southern sky and the relatively short follow-up time ($