We use a global 5-km resolution model to analyze the air-sea interactions during a katabatic storm in the Irminger Sea originating from the Ammassalik valleys. Katabatic storms have not yet been resolved in global climate models, raising the question of whether and how they modify water masses in the Irminger Sea. Our results show that dense water forms along the boundary current and on the shelf during the katabatic storm due to the heat loss caused by the high wind speeds and the strong temperature contrast. The dense water contributes to the lightest upper North Atlantic Deep Water as upper Irminger Sea Intermediate Water and thus to the lower limb of the Atlantic Meridional Overturning Circulation (AMOC). The katabatic storm triggers a polar low, which in turn amplifies the near-surface wind speed due to the superimposed pressure gradient, in addition to acceleration from a breaking mountain wave. Overall, katabatic storms account for up to 25% of the total heat loss (20 January 2020 to 30 September 2021) over the Irminger shelf of the Ammassalik area. Resolving katabatic storms in global models is therefore important for the formation of dense water in the western boundary current of the Irminger Sea, which is relevant to the AMOC, and for the large-scale atmospheric circulation by triggering polar lows.