Synthesis of 1,4,7,10-Tetra-azacyclododecan-1,4,7,10-tetra-azidoethylacetic Acid (DOTAZA) and Related "Clickable" DOTA Derivatives

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Autor/in:
Erscheinungsjahr:
2014
Medientyp:
Text
Schlagworte:
  • chelates
  • click chemistry
  • coordination modes
  • macrocycles
  • X-ray diffraction
Beschreibung:
  • Herein, we report the synthesis of two enantiomeric DOTAZA esters and a related DOT3AZA ester. These compounds are tunable analogues of the well-known chelator DOTA and can be easily functionalized through click chemistry of the side-chain azide groups. Like DOTA, DOTAZA forms complexes with various di- and trivalent metals, as demonstrated in the synthesis and structural analysis of Cu - DOTAZA and the preparation of Gd - DOTAZA. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Lizenz:
  • info:eu-repo/semantics/closedAccess
Quellsystem:
Forschungsinformationssystem der UHH
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Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/568e000f-cbd2-40ec-9a10-0b472ab5510c