Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography

Link:
Autor/in:
Verlag/Körperschaft:
Hamburg University of Technology
Erscheinungsjahr:
2005
Medientyp:
Text
Schlagworte:
  • 1-Phenyl-1-propanol
  • adsorption isotherm
  • enantioseparation
  • supercritical fluid-simulated moving bed chromatography
  • triangle theory
  • 500: Naturwissenschaften
  • 530: Physik
Beschreibung:
  • The enantioseparation of 1-phenyl-1-propanol through the supercritical fluid-simulated moving bed (SF-SMB) process is studied. Non-linear isotherms were measured on an analytical column, and used together with the triangle theory for SMB design to select operating conditions for the SF-SMB. Experiments were carried out on a pilot-scale SF-SMB plant at conditions that corresponded to the non-linear range of the isotherm. Under conditions of low feed concentration, complete separation (extract purity=99.5%; raffinate purity=98.4%) was achieved. Under conditions of larger feed concentration, the best separation corresponded to an extract purity of 98.0% and a raffinate purity of 94.0%, and yielded a productivity of 110g of racemate per kg stationary phase per day. © 2005 Elsevier B.V. All rights reserved.
Beziehungen:
DOI 10.1016/j.chroma.2005.02.040
Quellsystem:
TUHH Open Research
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oai:tore.tuhh.de:11420/4703