Characterization of JC virus-specific CD4+ T cell epitopes in healthy individuals
,
Charakterisierung JC Virus-spezifischer CD4+ T Zell Epitope in Gesunden
Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
Erscheinungsjahr:
2013
Medientyp:
Text
Schlagworte:
Progressive Multifokale Leukenzephalopathie
Epitopkartierung
Progressive Multifocal Leukoencephalopathy
Epitope mapping
610 Medizin, Gesundheit
44.45 Immunologie
44.90 Neurologie
Polyoma-Virus
Multiple Sklerose
ddc:610
Polyoma-Virus
Multiple Sklerose
Beschreibung:
Infection with John Cunningham virus (JCV) is very common in humans and usually remains asymptomatic in healthy individuals. However, under circumstances of severe immunocompromise, the polyomavirus JC may cause progressive multifocal leukoencephalopathy (PML), a life-threatening demyelinating disease of the human brain. PML preferentially occurs in situations of compromised CD4+ T cell function or number and little is known about the JCV epitopes recognized by CD4+ T cells. In this study, we mapped the JCV-specific CD4+ T cell response in healthy individuals using proliferation assays with peptides spanning the entire JCV proteome. Our aim was to obtain a better understanding of the mechanisms assuring immune control of JCV.