Distinguishing quarks from gluons based on low-level detector output is one of the most challenging applications of multi-variate and machine learning techniques at the LHC. We first show the performance of our 4-vector-based LoLa tagger without and after considering detector effects. We then discuss two benchmark applications, mono-jet searches with a gluon-rich signal and di-jet resonances with a quark-rich signal. In both cases an immediate benefit compared to the standard event-level analysis exists.