Adrenergic beta-Antagonists/adverse effects/*therapeutic use
*Aged
Bisoprolol/adverse effects/*therapeutic use
Carbazoles/adverse effects/*therapeutic use
Forced Expiratory Volume/drug effects
Heart Failure/*drug therapy/physiopathology
Heart Rate/drug effects
Propanolamines/adverse effects/*therapeutic use
Humans
Male
Female
Treatment Outcome
Europe
Double-Blind Method
Dose-Response Relationship, Drug
Adrenergic beta-Antagonists/adverse effects/*therapeutic use
*Aged
Bisoprolol/adverse effects/*therapeutic use
Carbazoles/adverse effects/*therapeutic use
Forced Expiratory Volume/drug effects
Heart Failure/*drug therapy/physiopathology
Heart Rate/drug effects
Propanolamines/adverse effects/*therapeutic use
Beschreibung:
Various beta-blockers with distinct pharmacological profiles are approved in heart failure, yet they remain underused and underdosed. Although potentially of major public health importance, whether one agent is superior in terms of tolerability and optimal dosing has not been investigated. The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure.
Various beta-blockers with distinct pharmacological profiles are approved in heart failure, yet they remain underused and underdosed. Although potentially of major public health importance, whether one agent is superior in terms of tolerability and optimal dosing has not been investigated. The aim of this study was therefore to compare the tolerability and clinical effects of two proven beta-blockers in elderly patients with heart failure.