Laser-plasma acceleration (LPA) is a compact technique to accelerate electron bunches to highly relativistic energies, making it a promising candidate to power radiation sources for industrial or medical applications. We report on the generation of electron beams from an 80 MeV-level LPA setup based on ionization injection (II) over a duration of 8 hours at a repetition rate of 2.5 Hz, resulting in 72,000 consecutive shots with charge injection and acceleration. Over the full operation time the moving averages of the total beam charge of 14.5 pC and the charge between 70-80 MeV did not drift on a detectable level. The largest source of shot-To-shot jitter was in the beam charge (26% standard deviation), which was most strongly correlated with fluctuations in the plasma density (3.6% standard deviation). Particle-in-cell simulations demonstrate that this was chiefly caused by stronger laser self-focusing in higher density plasmas, which significantly increased the ionized charge along with the emittance of the beam. The nonlinearity of this process imposes tight constraints on the reproducibility of the laser-plasma conditions required for a low jitter II-LPA output if self-focusing plays a role in the laser evolution.