Our paper describes the setup and the results of an empirical study on comparison of usability and performance while using two different input methods for training of nursing procedures in virtual reality: hand-held controller input and markerless hand tracking. As part of a research project funded by the German Ministry of Health, our study features the aseptic wound cleansing with tweezers and swabs. Our results indicate that the input method could have no significant impact on performance, but ratings on usability show a trend in favor of controller input.