Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina

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Erscheinungsjahr:
2017
Medientyp:
Text
Schlagworte:
  • dk/atira/pure/publikationen_lom_relevant/publikation_ist_nicht_scoring_relevant
  • Hamburg Center of Neuroscience (HCNS)
  • Journal Article
Beschreibung:
  • Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina. Double-immunofluoresence labeling and electron microscopic analysis revealed a presynaptic localization of GluK5 in the outer plexiform layer. Unexpectedly, we found GluK5 almost exclusively localized to the presynaptic ribbon of photoreceptor terminals. Moreover, in GluK5-deficient mutant mice the structural integrity of synaptic ribbons was severely altered pointing to a novel function of GluK5 in organizing synaptic ribbons in the presynaptic terminals of rod photoreceptors.

Lizenz:
  • info:eu-repo/semantics/openAccess
Quellsystem:
Forschungsinformationssystem des UKE

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Quelldatensatz
oai:pure.atira.dk:publications/953a4051-d4f1-4f2c-b74c-8a02c19e25f9