Open data (OD) use and the opening of data have become major strategic objectives in different communities. Nevertheless, the potential of OD is still not leveraged in many areas. In this work, we focus the OD impact information systems research. We review the respective literature for different domains of OD research and analyze cases of data-intensive decision support systems in transportation as well as open research grid systems. The resulting changes, challenges, and opportunities that OD causes are categorized according to different OD activities in IS research. Hence, they may serve as an agenda to foster OD practices, platforms, and administration in the area.