Noradrenergic arousal after encoding reverses the course of systems consolidation in humans

Link:
Autor/in:
Erscheinungsjahr:
2021
Medientyp:
Text
Schlagworte:
  • Adult
  • Arousal
  • Double-Blind Method
  • Female
  • Hippocampus/drug effects
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Memory Consolidation/drug effects
  • Memory, Episodic
  • Memory, Long-Term/drug effects
  • Norepinephrine/pharmacology
  • Recognition, Psychology/drug effects
  • Yohimbine/pharmacology
  • Young Adult
Beschreibung:
  • It is commonly assumed that episodic memories undergo a time-dependent systems consolidation process, during which hippocampus-dependent memories eventually become reliant on neocortical areas. Here we show that systems consolidation dynamics can be experimentally manipulated and even reversed. We combined a single pharmacological elevation of post-encoding noradrenergic activity through the α2-adrenoceptor antagonist yohimbine with fMRI scanning both during encoding and recognition testing either 1 or 28 days later. We show that yohimbine administration, in contrast to placebo, leads to a time-dependent increase in hippocampal activity and multivariate encoding-retrieval pattern similarity, an indicator of episodic reinstatement, between 1 and 28 days. This is accompanied by a time-dependent decrease in neocortical activity. Behaviorally, these neural changes are linked to a reduced memory decline over time after yohimbine intake. These findings indicate that noradrenergic activity shortly after encoding may alter and even reverse systems consolidation in humans, thus maintaining vividness of memories over time.
Lizenz:
  • info:eu-repo/semantics/openAccess
Quellsystem:
Forschungsinformationssystem der UHH

Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/d00baff1-8cda-4c14-b228-fe1a9645e66e