Nephrotoxic Nephritis (NTN) : Possible new therapeutic strategy using DHMEQ, a nuclear uptake inhibitor of NF-kappa B
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Nephrotoxische Nephritis (NTN) : Mögliche neue therapeutische Strategie mit DHMEQ, ein nukleares Aufnahme Inhibitor von NF-kappa B
Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
Erscheinungsjahr:
2012
Medientyp:
Text
Schlagworte:
Glomerulonephritiden
Nephrotoxische Nephritiden
NF-kappa B
DHMEQ
Glomerulonephritis
Nephrotoxic Nephritis
NF-kappa B
DHMEQ
610 Medizin, Gesundheit
44.38 Pharmakologie
44.52 Therapie
44.61 Innere Medizin
44.88 Urologie, Nephrologie
ddc:610
Beschreibung:
Inflammatory glomerular kidney diseases (glomerulonephritis) are causing, in spite of some progress in the therapy, still in about 20-30% of the cases end stage renal disease. Understanding the pathogenesis of inflammatory diseases persistently improved further in the past years through following reasons among others: By describing the role of transcription factors, that all ahead of NF kappa B, with that induction of inflammatory diseases occurs and By showing, that NF kappa B has also a decisive importance in the resolution phase of inflammation processes. The team was able to publish recently that it comes after induction of experimental kidney diseases into a two phase activation of NF kappa B. In the first peak, the p65/p50 heterodimer protein complex dominates, in the second peak the p50/p50 homodimers. Goal of the graduation work therefore is to examine the effect of the inhibition of the nuclear reception of NF kappa B complexes by means of in vivo application of DHMEQ at different times after induction of the NTN in wild type mice.