Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
Erscheinungsjahr:
2018
Medientyp:
Text
Schlagworte:
Nucleotide
Antibiotikum
Prodrugs
nucleotide
antibiotics
prodrug
540 Chemie
35.50 Organische Chemie: Allgemeines
ddc:540
Beschreibung:
This thesis aimed at conjugating two aryl-ureidothiophene carboxylic acids with moieties that provide the capacity to coordinate FeIII. In addition, spacer groups were introduced to facilitate enzymatic prodrug activation. The FeIII-coordination of the siderophore-type prodrugs was evaluated in a competitive assay to yield relative affinities. The antibiotic activity of all prodrugs, i.e. lipophilic, cationic and functionalized, was determined. In a further aspect, this thesis aimed at developing synthetic access towards AB-masked derivatives of cNMPs, (d)ADPR and NAADP. Introduction of the AB-mask in a (site-) specific way and thus in total synthesis approaches was preferably considered. Based on the complexity of the dinucleotides in molecular structure, convergent synthesis routes with a final coupling step were designed.