This study presents preliminary observations of a collection of manuscripts from a private household in the town of Lo Monthang, in Mustang, Nepal. The manuscripts, which were used by generations of royal priests belonging to a family named Drangsong, contain for the most part ritual texts for the protection and prosperity of the kingdom of Mustang and its subjects. The collection of 280 manuscripts, assembled from different parts of Tibet and the Himalaya over six centuries, was subjected to codicological and text-historical research. The shuffled folios were first sorted into distinct texts that were numbered and photographed. Further analyses were then undertaken on the basis of images and notes taken in situ, as well as loose pieces of paper from the most damaged leaves identified within individual volumes. Knowledge of the materials and ritual practices involved in the creation of physical objects have been applied to better understand the textual, material and social aspects of this unknown, unique and endangered collection.