In cities, social well-being faces obstacles posed by globalization, demographic and climate change, new forms of social organization, and the fragmentation of lifestyles. These changes affect the vulnerability of city societies and impact their health-related urban well-being (UrbWellth). The conceptual model introduced in this paper systematizes the relevant variables while considering previous research, and establishes the target value UrbWellth. The model differs from existing approaches mainly in the analytical distinctions it suggests. These allow us to group the relevant urban influence variables into four sectors and enable a more general and abstract consideration of health-related urban relations. The introduction of vulnerability as a filter and transfer function acts as an effect modifier between UrbWellth and the various urban variables.