Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report
- Link:
- Autor/in:
- Erscheinungsjahr:
- 2013
- Medientyp:
- Text
- Schlagworte:
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- Anti-N-Methyl-D-Aspartate Receptor Encephalitis
- Encephalitis, Viral
- Herpesvirus 1, Human
- Humans
- Male
- Young Adult
- Beschreibung:
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Relapsing symptoms post herpes simplex virus 1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) a true viral relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, and response to acyclovir therapy) or 2) a disorder postulated to be immune-mediated (CSF negative for HSV, no new necrotic lesions, and no response to acyclovir).(1,2) It has been suggested that this immune-mediated disorder may be related to NMDA receptor (NMDAR) antibodies,(3) and we recently reported a child in whom relapsing symptoms post HSVE were the presentation of anti-NMDAR encephalitis.(4) We report an adult with this disorder, demonstrate that synthesis of NMDAR antibodies began after HSVE, and show that relapsing symptoms were due to steroid-responsive anti-NMDAR encephalitis.
- Lizenz:
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- info:eu-repo/semantics/restrictedAccess
- Quellsystem:
- Forschungsinformationssystem des UKE
Interne Metadaten
- Quelldatensatz
- oai:pure.atira.dk:publications/e7ecc2b7-6a79-4f92-8e15-b794174aba31