Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report

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Autor/in:
Erscheinungsjahr:
2013
Medientyp:
Text
Schlagworte:
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis
  • Encephalitis, Viral
  • Herpesvirus 1, Human
  • Humans
  • Male
  • Young Adult
Beschreibung:
  • Relapsing symptoms post herpes simplex virus 1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) a true viral relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, and response to acyclovir therapy) or 2) a disorder postulated to be immune-mediated (CSF negative for HSV, no new necrotic lesions, and no response to acyclovir).(1,2) It has been suggested that this immune-mediated disorder may be related to NMDA receptor (NMDAR) antibodies,(3) and we recently reported a child in whom relapsing symptoms post HSVE were the presentation of anti-NMDAR encephalitis.(4) We report an adult with this disorder, demonstrate that synthesis of NMDAR antibodies began after HSVE, and show that relapsing symptoms were due to steroid-responsive anti-NMDAR encephalitis.

Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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Quelldatensatz
oai:pure.atira.dk:publications/e7ecc2b7-6a79-4f92-8e15-b794174aba31