We briefly review existing proposals for the renormalization of the Cabibbo-Kobayashi-Maskawa (CKM) matrix and study the numerical effects of several of them on the W-boson hadronic partial decay widths. We then use these results to evaluate the relative shifts on the CKM parameters |V-ij|(2) induced by the quark-mixing renormalization effects, as well as their scheme dependence. We also discuss the implications of this analysis for the most precise unitarity test of the CKM matrix.