Sustainability is pivotal for the strategic success of Science and Technology Parks (STPs), as it integrates innovation with global goals for sustainable development. This study explores the role of STPs in advancing the United Nations’ Sustainable Development Goals (SDGs), particularly focusing on their contributions to bridging technological gaps between developed and developing regions. Using a global survey of 35 parks, this research provides insights into their level of engagement with the SDGs, revealing areas of excellence and opportunities for improvement. A key contribution of this paper is its detailed analysis of the SDGs most emphasized by STPs and its classification of parks based on their strategic orientation towards sustainability. The findings advance knowledge on how STPs act as innovation intermediaries, enhancing regional development and fostering sustainability. These results offer actionable strategies for aligning STPs’ operations with the 2030 Agenda, contributing to the global discourse on sustainable organizational practices and innovation systems.