Genomes: At the edge of Chaos with maximum information capacity

Link:
Autor/in:
Verlag/Körperschaft:
World Scientific Publishing
Erscheinungsjahr:
2016
Medientyp:
Text
Schlagworte:
  • DNA sequences
  • DNA
  • Markov chain
  • Proteins
  • Molecular Dynamics Simulation
  • Molecular Dynamics
  • DNA sequences
  • DNA
  • Markov chain
  • Proteins
  • Molecular Dynamics Simulation
  • Molecular Dynamics
Beschreibung:
  • We propose an order index, φ, which quantifies the notion of "life at the edge of chaos" when applied to genome sequences. It maps genomes to a number from 0 (random and of infinite length) to 1 (fully ordered) and applies regardless of sequence length and base composition. The 786 complete genomic sequences in GenBank were found to have φ values in a very narrow range, 0.037 ± 0.027. We show this implies that genomes are halfway towards being completely random, namely, at the edge of chaos. We argue that this narrow range represents the neighborhood of a fixed-point in the space of sequences, and genomes are driven there by the dynamics of a robust, predominantly neutral evolution process.
Lizenz:
  • info:eu-repo/semantics/closedAccess
Quellsystem:
Forschungsinformationssystem der UHH

Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/8e25ce3d-b9c7-4ff0-8ad1-811dd2df69fd