Throughout the last decades, the increasing volume of information and operational workload in logistics caused a sharp interest in the automation of physical and informational logistical processes. Companies, institutions, and logistics stakeholders considering this aspect can react more efficiently to changes and disturbances resulting in more accurate planning, extending customer and product individualization while, in many cases, reducing operating costs. This resulted in advances in several logistics sectors, such as maritime shipping, multi-modal transport, urban logistics, warehousing, and inventory management. Computational logistics, as the driver between decision making and operations, has become a key component for economic and industrial growth. Computational logistics covers the management of logistics’ activities and tasks through the joint use of information and communication technologies and advanced decision support and optimization techniques. It is applied in several areas, e.g., the flow and storage of goods and services as well as the flow of related information. In this context, modeling and algorithmic approaches are developed, verified, and applied for planning and executing complex logistics tasks, e.g., for finding the most efficient routing plan and schedule to transport passengers or distribute goods. The models and algorithms are integrated with computing technologies, not only to get satisfactory results in reasonable times but also to exploit interactivity with the decision maker through visual interfaces, and to extract knowledge from data to improve future decision making. This promotes the joint effort of practitioners and scholars for better understanding and solving the logistics problems at hand. The International Conference on Computational Logistics (ICCL) is a forum where recent advances in the computational logistics research area are presented and discussed. This volume offers a selection of 42 peer-reviewed papers out of the 111 contributions submitted to the this year’s edition of ICCL, held virtually at the University of Twente, Enschede (The Netherlands), during September 27–29, 2021.