The formation and evolution of galaxies in the local Supercluster have very likely lead to the acceleration of energetic particles by individ-ual galaxies as well as in large scale shocks in merger events. Here, we investigate the signatures of cosmic-rays up to energies of a few 10 19 eV which are efficiently confined in the intra-cluster medium. Subsequent photo-pion production and pair-production/inverse Compton cascades lead to a large-scale anisotropy at TeV and EeV-energies along the super-galactic plane. Additionally, energetic neutrinos are produced. We provide predictions and discuss implications for the cosmic-ray energy density in the local Supercluster.