We theoretically investigate the thermodynamics of an interacting inhomogeneous two-component Fermi gas in an optical lattice. Motivated by a recent experiment by L. Hackermuller et al., Science 327, 1621 (2010), we study the effect of the interplay between thermodynamics and strong correlations on the size of the fermionic cloud. We use dynamical mean-field theory to compute the cloud size, which in the experiment shows an anomalous expansion behavior upon increasing attractive interaction. We confirm this qualitative effect but, assuming adiabaticity, we find quantitative agreement only for weak interactions. For strong interactions we observe significant nonequilibrium effects which we attribute to a dynamical arrest of the particles due to increasing correlations. DOI: 10.1103/PhysRevLett.110.075302