In this Perspective, we reflect on a decade of research on the protein corona and contemplate its broad implications for future science and engineering at the bio–nano interface. Specifically, we focus on the physical origins and time evolution of the protein corona, differences in the nanoparticle–protein entity in in vitro and in vivo environments, the role of stealth polymers to minimize the formation of the protein corona, relevant computational and theoretical developments, and the “biocorona”, a concept extrapolated from the field of nanomedicine. We conclude the Perspective by outlining future directions and opportunities concerning the protein corona in the coming decade.