We investigate molecule molecule, as well as molecule substrate, interactions of phthalocyanine molecules deposited on graphene. In particular, we show how to tune the self-assembly of molecular lattices in two dimensions by intercalation of transition metals between graphene and Ir(111): modifying the surface potential of the graphene layer via intercalation leads to the formation of square, honeycomb, or Kagome lattices. Finally, we demonstrate that such surface induced molecular lattices are stable even at room temperature.