Inefficient use of fertilizers is not only an environmental hazard but have substantial economic loss in term of efficiency of crop and profit of farmers. Keeping in view this issue, this study focused to analyzing the technical efficiency of balance and imbalance users of fertilizers by utilizing stochastic production frontier approach. A set of primary data is used, collected from district Multan in Cotton-Wheat cropping zone of Punjab province. The results are indicated that average technical efficiency is higher with balance users of fertilizers. It is found that technical efficiency improved by 14 points (p0.00) from 70 to 84 percent by proper usage of fertilizers in balance ratio (N: P). The best policy option is to determine the proper nutrients requirements of soil by soil or plant analysis and then apply fertilizers in accordance with the requirements of soil and crop to obtain high efficiency of crop and maximizing profit of farmers. There should improvement of education and extension services to better understanding and adoption practices by farmers about balance usage of fertilizers in order to obtain high yield of wheat.