A highly effective, nontoxic T1 MR contrast agent based on ultrasmall PEGylated iron oxide nanoparticles

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Autor/in:
Erscheinungsjahr:
2009
Medientyp:
Text
Schlagworte:
  • Iron oxides
  • Nanomagnetics
  • Superparamagnetic iron
  • Magnetic Fluids
  • Nanoparticles
  • Iron oxides
  • Nanomagnetics
  • Superparamagnetic iron
  • Magnetic Fluids
  • Nanoparticles
Beschreibung:
  • In this study we systematically developed a potential MR T1 contrast agent based on very small PEGylated iron oxide nanoparticles. We adjusted the size of the crystalline core providing suitable relaxometric properties. In addition, a dense and optimized PEG coating provides high stability under physiological conditions together with low cytotoxicity and low nonspecific phagocytosis into macrophage cells as a part of the reticulo endothelial system at biologically relevant concentrations. The as developed contrast agent has the lowest r2/r1 ratio (2.4) at 1.41 T reported so far for PEGylated iron oxide nanoparticles as well as a r 1 relaxivity (7.3 mM-1 s-1) that is two times higher compared to that of Magnevist as a typical T1 contrast agent based on gadolinium as a clinical standard. © 2009 American Chemical Society.
Lizenz:
  • info:eu-repo/semantics/closedAccess
Quellsystem:
Forschungsinformationssystem der UHH
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Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/071a7bee-de43-44c1-b57a-35be39d307a8