Current aspects on transdermal patch technology under special consideration of the rotigotine patch , Aktuelles zur Pflastertechnologie unter spezieller Berücksichtigung des Rotigotinpflasters

The cutaneous administration of drugs has considerably gained importance over the last years. By this route controlled, constant blood levels can be achieved, the first-pass effect can be avoided, and the lower application frequency, especially of transdermal patches, has a highly positive effect on compliance. On account of its physicochemical properties such as high lipophilicity, low melting point and thus good solubility in the stratum corneum, as well as its low molecular weight, the drug rotigotine offers excellent prerequisites for cutaneous administration with a desired systemic action.