Radical Aromatic Trifluoromethylthiolation: Photoredox Catalysis vs. Base Mediation

Link:
Autor/in:
Erscheinungsjahr:
2017
Medientyp:
Text
Schlagworte:
  • Olefins
  • Indicators and Reagents
  • Unactivated alkenes
  • Catalysis
  • Synthesis (Chemical)
  • Catalysts
  • Olefins
  • Indicators and Reagents
  • Unactivated alkenes
  • Catalysis
  • Synthesis (Chemical)
  • Catalysts
Beschreibung:
  • Trifluoromethyl aryl sulfides (Ar-SCF3) constitute highly attractive building blocks due to their exceptional lipophilicity and chemical properties. Related protocols of radical aromatic trifluoro-methylthiolation of arenediazonium salts were developed that are based on the facile generation of intermediate aryl radicals. Their reactions with commercial F3CS-SCF3 under very mild conditions afforded a diverse set of Ar-SCF3 (< 90\% yield). Direct comparison of photoredox catalysis \{eosin Y or {[}Ru(bpy)(3)]Cl-2\} with the weak base-mediated dark reaction documented higher synthetic efficiency of the former but higher operational simplicity of the latter strategy.
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem der UHH

Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/ca61fd92-5d09-4196-8f74-bf1b668405a5