Amplification of 8q21 in breast cancer is independent of MYC and associated with poor patient outcome.

Link:
Autor/in:
Erscheinungsjahr:
2010
Medientyp:
Text
Schlagworte:
  • Adult
  • Humans
  • Aged
  • Female
  • Middle Aged
  • Aged, 80 and over
  • Treatment Outcome
  • Prognosis
  • Gene Dosage
  • Kaplan-Meier Estimate
  • Gene Amplification
  • In Situ Hybridization, Fluorescence
  • Chromosomes, Human, Pair 8 genetics
  • Tissue Array Analysis
  • Drug Resistance, Neoplasm genetics
  • Breast Neoplasms genetics
  • Genes, myc
  • Adult
  • Humans
  • Aged
  • Female
  • Middle Aged
  • Aged, 80 and over
  • Treatment Outcome
  • Prognosis
  • Gene Dosage
  • Kaplan-Meier Estimate
  • Gene Amplification
  • In Situ Hybridization, Fluorescence
  • Chromosomes, Human, Pair 8 genetics
  • Tissue Array Analysis
  • Drug Resistance, Neoplasm genetics
  • Breast Neoplasms genetics
  • Genes, myc
Beschreibung:
  • Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the 8q21 amplicon is less clear. The breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative target genes TPD52 and WWP1. To understand the effect of proximal 8q21 amplification on breast cancer phenotype and patient prognosis, we analyzed 8q21 copy number changes using fluorescence in situ hybridization (FISH) in a tissue microarray containing more than 2000 breast cancers. Amplification at 8q21 was found in 3% of tumors, and was associated with medullary type (P
  • Copy number gains involving the long arm of chromosome 8, including high-level amplifications at 8q21 and 8q24, have been frequently reported in breast cancer. Although the role of the MYC gene as the driver of the 8q24 amplicon is well established, the significance of the 8q21 amplicon is less clear. The breast cancer cell line SK-BR-3 contains three separate 8q21 amplicons, the distal two of which correspond to putative target genes TPD52 and WWP1. To understand the effect of proximal 8q21 amplification on breast cancer phenotype and patient prognosis, we analyzed 8q21 copy number changes using fluorescence in situ hybridization (FISH) in a tissue microarray containing more than 2000 breast cancers. Amplification at 8q21 was found in 3% of tumors, and was associated with medullary type (P
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/6ac64154-30b0-4427-b471-c451e3a57f6a