Organophosphates (OPs) are toxic chemicals that are almost ubiquitous in our environment and they pose a significant health risk to millions of people worldwide. While the acute toxicity of OPs has been studied extensively, the effects of repeated exposures to levels of OPs not associated with acute toxicity, especially on cognitive function are poorly understood. Using animal models and in vitro methods we have established that repeated (subacute) exposures to some OPs can lead to protracted deficits in several domains of cognition, and that impairment in axonal transport may represent a potential underlying mechanism of these adverse effects.
This paper is part of: "2017 International Aircraft Cabin Air Conference : Conference Proceedings". In: Journal of Health and Pollution, Vol. 9, No. 24 (Dec. 2019)