The impact of the number of cores on tissue microarray studies investigating prostate cancer biomarkers.

Link:
Autor/in:
Erscheinungsjahr:
2012
Medientyp:
Text
Schlagworte:
  • Humans
  • Male
  • Aged
  • Middle Aged
  • Immunohistochemistry
  • Neoplasm Staging
  • Protein Array Analysis/methods
  • Neoplasm Grading
  • Ki-67 Antigen/*analysis/biosynthesis
  • Prostatic Neoplasms/*chemistry/metabolism/pathology
  • Tumor Markers, Biological/*analysis/biosynthesis
  • Tumor Suppressor Protein p53/*analysis/biosynthesis
  • Humans
  • Male
  • Aged
  • Middle Aged
  • Immunohistochemistry
  • Neoplasm Staging
  • Protein Array Analysis/methods
  • Neoplasm Grading
  • Ki-67 Antigen/*analysis/biosynthesis
  • Prostatic Neoplasms/*chemistry/metabolism/pathology
  • Tumor Markers, Biological/*analysis/biosynthesis
  • Tumor Suppressor Protein p53/*analysis/biosynthesis
Beschreibung:
  • Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in triplet cores taken from three different areas of 3,261 prostate cancer tissue blocks. Both p53 and Ki67 labeling index were linked to advanced tumor stage (p
  • Most tissue microarray studies have used a single 0.6-mm tissue core per donor tissue. It has been suggested that multiple cores per donor can increase the representativity of tissue microarray studies. To estimate the potential benefit of multiple cores, we analyzed Ki67 and p53 in triplet cores taken from three different areas of 3,261 prostate cancer tissue blocks. Both p53 and Ki67 labeling index were linked to advanced tumor stage (p
Lizenz:
  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

Interne Metadaten
Quelldatensatz
oai:pure.atira.dk:publications/a1b4b94c-aca3-4178-93a0-50fdb7e0c258