Expression of podoplanin in nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumours.

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Erscheinungsjahr:
2012
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Beschreibung:
  • Keratocystic odontogenic tumour (KCOT) is a benign oral neoplasm of odontogenic origin. The majority of KCOT develop sporadically. The main differential diagnosis of KCOT is from other odontogenic cysts and ameloblastoma. In the rare nevoid basal cell carcinoma syndrome (NBCCS, synonym: Gorlin(-Goltz)-Syndrome), however, KCOTs are frequently detected and may be the initial sign of this clinical syndrome. Podoplanin is a mucin-type transmembrane protein found in podocytes of human kidneys homologous to T1?-2. The expression of podoplanin in some other non-endothelial tissues raised our interest in studying this antibody in tissues of odontogenic origin. Recently, we reported podoplanin expression in sporadic cases of KCOT. We intended to investigate the podoplanin expression in KCOTs associated with NBCCS.
  • Keratocystic odontogenic tumour (KCOT) is a benign oral neoplasm of odontogenic origin. The majority of KCOT develop sporadically. The main differential diagnosis of KCOT is from other odontogenic cysts and ameloblastoma. In the rare nevoid basal cell carcinoma syndrome (NBCCS, synonym: Gorlin(-Goltz)-Syndrome), however, KCOTs are frequently detected and may be the initial sign of this clinical syndrome. Podoplanin is a mucin-type transmembrane protein found in podocytes of human kidneys homologous to T1?-2. The expression of podoplanin in some other non-endothelial tissues raised our interest in studying this antibody in tissues of odontogenic origin. Recently, we reported podoplanin expression in sporadic cases of KCOT. We intended to investigate the podoplanin expression in KCOTs associated with NBCCS.
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  • info:eu-repo/semantics/restrictedAccess
Quellsystem:
Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/b6d559e0-8e4f-48dc-b244-429ef6e6b8ed