Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases:Journal of Biological Chemistry

Link:
Autor/in:
Erscheinungsjahr:
2023
Medientyp:
Text
Schlagworte:
  • codon
  • mRNA
  • mRNA translation
  • pathogenic mutations
  • SNPs
  • tRNA
  • tRNA abundance
  • Codon
  • Humans
  • Mutation
  • Polymorphism, Single Nucleotide
  • Protein Biosynthesis
  • RNA, Messenger
  • RNA, Transfer
  • Time Factors
  • Genes
  • messenger RNA
  • transfer RNA
  • Foldings
  • Human disease
  • MRNA
  • MRNA translation
  • Pathogenic mutation
  • SNP
  • Translation speed
  • TRNA
  • TRNA abundance
  • disease severity
  • gene expression
  • genetic association
  • genetic disorder
  • genetic variability
  • human
  • missense mutation
  • mutational analysis
  • phenotype
  • protein folding
  • Review
  • RNA conformation
  • RNA processing
  • RNA translation
  • single nucleotide polymorphism
  • genetics
  • metabolism
  • mutation
  • protein synthesis
  • time factor
  • Proteins
Beschreibung:
  • Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics, and therefore cotranslational folding and function of the encoded protein. The tRNA pool, whose composition and abundance change in a cell- and tissue-dependent manner, is the main factor which determines mRNA translation velocity. In this review, we discuss a group of pathogenic mutations, in the coding sequences of either protein-coding genes or in tRNA genes, that alter mRNA translation dynamics. We also summarize advances in tRNA biology that have uncovered how variations in tRNA levels on account of genetic mutations affect protein folding and function, and thereby contribute to phenotypic diversity in clinical manifestations. © 2023 The Authors
Lizenz:
  • info:eu-repo/semantics/openAccess
Quellsystem:
Forschungsinformationssystem der UHH
Interne Metadaten
Quelldatensatz
oai:www.edit.fis.uni-hamburg.de:publications/9c867c70-2b3c-4424-9ea3-5f8baff58289