Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome

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Erscheinungsjahr:
2015
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Text
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  • Purpose: Patients with Marfan syndrome require repeated imaging for monitoring of aortic root aneurysms. Therefore, we evaluated the agreement and reproducibility of cine-MRI and echocardiography measurements of the sinuses of Valsalva in patients with suspected Marfan syndrome. Materials and Methods: 51 consecutive patients with suspected Marfan syndrome were prospectively examined using cine-MRI and echocardiography. Two readers independently measured aortic root diameters at the level of the sinuses of Valsalva in both cine-MRI and echocardiography. Statistics included intraclass correlation coefficient, Pearson correlation coefficient, Bland-Altman analysis, and two-sided t-test. Results: In 38 of the 51 individuals (74.5 %), the diagnosis of Marfan syndrome was established according to the criteria of the Ghent-2 nosology. Cine-MRI measurements of the sinuses of Valsalva revealed a strong correlation with echocardiography (r = 0.929), but a statistically significant bias of -1.0 mm (p < 0.001). The mean absolute diameter for sinuses of Valsalva obtained by cine-MRI was 32.3 ± 5.8 mm as compared to 33.4 ± 5.4 mm obtained by echocardiography. Interobserver agreement of measurements of the sinuses of Valsalva was higher for cine-MRI than for echocardiography (p = 0.029). Conclusion: Despite small, but statistically significant differences in terms of agreement and reproducibility, cine-MRI and echocardiographic measurements of aortic root diameters provide comparable results without a significant clinical difference. Therefore both techniques may be used for monitoring of the aortic root in patients with Marfan syndrome. Key points: • Cine-MRI (ICC: 0.93, CI: 0.88 - 0.96) and echocardiography (ICC: 0.90, CI: 0.82 - 0.94) allow assessment of aortic root diameters in patients with Marfan syndrome• Cine-MRI offers higher reproducibility of aortic root diameters than echocardiography (95 % limits of agreement of ± 3.6 mm versus ± 5.0 mm, p = 0.029)• Aortic root measurements with cine-MRI and echocardiography reveal a small (mean difference; -1.0 mm) but statistically significant offset (p = 0.0004) Citation Format: • Bannas P., Rybczynski M., Sheikhzadeh S. et al. Comparison of Cine-MRI and Transthoracic Echocardiography for the Assessment of Aortic Root Diameters in Patients with Suspected Marfan Syndrome. Fortschr Röntgenstr 2015; DOI: 10.1055/s-0035-1553224.

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  • info:eu-repo/semantics/restrictedAccess
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Forschungsinformationssystem des UKE

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oai:pure.atira.dk:publications/dd27066b-a6c6-444e-acc6-0fa3eab4b5ec