Neural development during human childhood and adolescence involves highly coordinated and sequenced events, characterized by both progressive and regressive processes. Despite a multitude of results demonstrating the age-dependent development of gray matter, white matter, and total brain volume, a reference curve allowing prediction of structural brain maturation is still lacking but would be clinically valuable. For the first time, the present study provides a validated reference curve for structural brain maturation during childhood and adolescence, based on structural MRI data.
Neural development during human childhood and adolescence involves highly coordinated and sequenced events, characterized by both progressive and regressive processes. Despite a multitude of results demonstrating the age-dependent development of gray matter, white matter, and total brain volume, a reference curve allowing prediction of structural brain maturation is still lacking but would be clinically valuable. For the first time, the present study provides a validated reference curve for structural brain maturation during childhood and adolescence, based on structural MRI data.